■ 고시 개정 전체내용 1차적으로 투약비용이 저렴한 항히스타민제를 투여하였으나 졸림 등 부작용이 있어 2차적으로 허가사항 범위 내에서 아래와 같은 기준으로 투여 시 요양급여를 인정하며, 동 인정기준 이외에는 약값 전액을 환자가 부담토록 함. - 아 래 - 가. 알레르기비염 나.두드러기, 습진ㆍ피부염, 피부가려움, 가려움발진(痒疹), 가려움을 동반한 보통건선 ■ 고시 신설 고시번호(시행일자) 고시 제2023-296호(2024.1.1.) ■ 고시 신설 사유 ○’23년 급여적정성 재평가 결과에 따라, 급여기준을 변경함 ■ 관련문헌 등 · Harrison's Principles of Internal Medicine(21판/2022) · Ocular surface disease: Cornea, Conjunctiva and Tear film(2013) · Cornea(2022) · Clinical Ocular Pharmacology(5판/2013) · Kanski's clinical ophthalmology(9판/2020) · Ophthalmology(6판/2023) · The Will's eye manual(8판/2021) · 흔히 보는 피부질환(3판/2015) · 약물치료학 제2권/제5개정 · Japanese guidelines for adult asthma(2020) · Japanese guidelines for allergic rhinitis(2020) · Japanese Guidelines for Diagnosis and Treatment of Urticaria in Comparison with Other Countries(2012) · Treatment of seasonal allergic rhinitis: An evidence-based focused 2017 guideline update(2017) · Okubo, Kimihiro, and Minoru Gotoh. "Inhibition of the antigen provoked nasal reaction by second-generation antihistamines in patients with Japanese cedar pollinosis." Allergology International 55.3 (2006): 261-269. · Furue, Masutaka, Hiroshi Terao, and Tetsuya Koga. "Effects of cetirizine and epinastine on the skin response to histamine iontophoresis." Journal of dermatological science 25.1 (2001): 59-63. · Leroy, T., and D. Van Neste. "DERMAL OBJECTIVE PHARMACODYNAMIC PROFILE OF CETIRIZINE AND EPINASTINE: TWO CONTROLLED, RANDOMISED, DOUBLE­BLIND, CROSSOVER STUDIES." International journal of clinical practice 56.8 (2002): 568-573. · Finegold, Ira, et al. "Efficacy and response with olopatadine versus epinastine in ocular allergic symptoms: a post hoc analysis of data from a conjunctival allergen challenge study." Clinical therapeutics 28.10 (2006): 1630-1638. · Borazan, Mehmet, et al. "Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo­controlled environmental trial." Acta Ophthalmologica 87.5 (2009): 549-554. · Fujishima, Hiroshi, Yuichi Ohashi, and Etsuko Takamura. "Efficacy of epinastine hydrochloride ophthalmic solution in allergic conjunctivitis by conjunctival cedar pollen allergen challenge." Annals of Allergy, Asthma & Immunology 113.4 (2014): 476-481. · Tagawa, Yoshiaki, et al. "Evaluating the efficacy of epinastine ophthalmic solution using a conjunctivitis allergen challenge model in patients with birch pollen allergic conjunctivitis." Allergology International 66.2 (2017): 338-343. · Abelson, Mark B., et al. "Efficacy and tolerability of ophthalmic epinastine assessed using the conjunctival antigen challenge model in patients with a history of allergic conjunctivitis." Clinical therapeutics 26.1 (2004): 35-47. · Whitcup, Scott M., et al. "Efficacy and tolerability of ophthalmic epinastine: a randomized, double-masked, parallel-group, active-and vehicle-controlled en